Challenges of Chemosensitivity Testing
نویسندگان
چکیده
منابع مشابه
Challenges of chemosensitivity testing.
One of the major goals in cancer therapeutics is to increase efficacy and reduce toxicity by tailoring therapy to individual patients. It is well known that tumors and patients are heterogeneous, and with every therapeutic approach, whether immunotherapy, chemotherapy, or antivascular strategy, patient response can be extremely variable, ranging from progression to complete responses. Understan...
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Since chemotherapy started in 1940s, chemosensitivity testing has been both a very attractive field and one fraught with potential pitfalls. Many methods were developed and brought initial promises, yet later ending in disappointment and were eliminated. For example, in the 1970s clonogenic assay was generally believed to be the best testing method for predicting clinical outcome. However, tech...
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In vitro chemosensitivity testing of anticancer agents for patient treatment has evolved gradually since the time of our report in 1978 (7) on the use of a human tumor cloning or tumor stem cell assay for this purpose. Although some technical problems remain, definite improvement has been seen in the frequency of in vitro sensitivity results with several assay systems {2-4). One important quest...
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As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of successful treatment and more importantly prevent the spread of the disease.
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BACKGROUND: Soft tissue sarcomas comprise less than 1% of all solid malignancies. The presentation and behavior of these tumors differs depending on location and histological characteristics. Standard therapy consists of complete surgical resection in combination with adjuvant radiotherapy. The role of chemotherapy is not clearly defined and is largely restricted to clinical trials. Only a limi...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-1656